As the 2024 NFL season approaches, the San Francisco 49ers and Buffalo Bills are set to face off, with predictions favoring the Bills as home underdogs following a bye week. The 49ers, who recently played a difficult schedule, may be overvalued, with betting odds potentially shifting towards Buffalo. Meanwhile, the Detroit Lions are emerging as strong contenders for the Super Bowl after a successful 2023 season, with expectations high for a further step forward under quarterback Jared Goff. In the preseason, the New England Patriots and New York Giants also enter as favorites in their respective matchups, with quarterback performances being a key factor. NFL futures betting continues to gain traction, with teams like the Kansas City Chiefs and 49ers considered top contenders for the Super Bowl. Bettors are advised to approach futures responsibly, focusing on long-term investments and conducting thorough research.