Multiple MLB series are set to begin or continue this weekend, with key matchups including the Seattle Mariners against the San Francisco Giants, the Los Angeles Dodgers hosting the Tampa Bay Rays, and the Oakland Athletics facing the Milwaukee Brewers. Meanwhile, the New York Mets are set to start a 10-game road trip against the San Diego Padres, while the Minnesota Twins face a crucial series against the St. Louis Cardinals as they strive for a playoff spot. In another series, the Toronto Blue Jays will play against the Los Angeles Angels at Rogers Centre. Additionally, the Washington Nationals will wrap up a series against the Colorado Rockies, aiming to break their current tie.