Karolina Pliskova, former world number one and 2016 US Open finalist, had to retire from her second-round match against Jasmine Paolini due to a left ankle injury, occurring just three points into the match. The match, held on Louis Armstrong Stadium, officially lasted only six minutes before Paolini was declared the winner with a score of 0-0. Paolini expressed her concern for Pliskova, stating it was disappointing to see her leave the court without playing a match, emphasizing the negative impact on tennis. With this withdrawal, Paolini advances to face Yulia Putintseva for a place in the last 16. Pliskova's early exit adds to a growing list of injuries affecting players at this year's US Open, highlighting the physical demands of the tournament.