Five individuals, including two doctors and Matthew Perry's personal assistant, have been charged in connection with the actor's death from a ketamine overdose last October. Prosecutors allege that the defendants exploited Perry's addiction issues, providing him with dangerous amounts of the anesthetic despite knowing the risks. U.S. Attorney Martin Estrada stated that one doctor questioned how much Perry would pay for ketamine, highlighting the defendants' unethical behavior. Perry, who had been seeking ketamine infusions for depression, was found dead in a hot tub after receiving multiple injections on the day of his death. Two of the charged individuals have already pleaded guilty, while others face serious charges, including distribution of ketamine and falsifying medical records. The ongoing investigation raises concerns about the misuse of ketamine, which has seen a rise in off-label prescriptions despite its associated dangers.