USC and LSU are set to clash in Las Vegas for the first time in 20 years, reigniting a historical rivalry stemming from their controversial dual national championships in 2003. Both teams, led by new quarterbacks Miller Moss for USC and Garrett Nussmeier for LSU, face significant pressure as they navigate the challenges of replacing Heisman-winning starters. Coaches Lincoln Riley and Brian Kelly are also entering critical third years, aiming to improve their defenses while managing high expectations. The game serves as a crucial opener for both teams amid a tough upcoming schedule, with the potential to shape their seasons. Additionally, Moss and Nussmeier's paths reflect a trend of quarterbacks navigating the complexities of collegiate football, with both players having waited for their opportunities behind established stars. This matchup not only holds historical significance but also sets the tone for their respective seasons ahead.