Matthew Perry, the 'Friends' star, died on October 28, 2023, from an accidental overdose of ketamine, which was not prescribed by a doctor. Federal and local law enforcement have made multiple arrests, including at least one doctor, in connection with the investigation into how Perry obtained the drug. The autopsy report indicated that ketamine caused cardiovascular overstimulation and respiratory depression, with contributing factors such as drowning and coronary artery disease. Perry had been undergoing ketamine infusion therapy for anxiety and depression, but the last session occurred a week and a half before his death. Authorities are continuing to investigate the circumstances surrounding the procurement of the ketamine, as it was linked to a larger network. Perry had a history of addiction and had been 19 months sober at the time of his death.