The Oropouche virus, also known as 'Sloth Fever,' has emerged in the United States, with 21 cases reported, primarily among travelers returning from Cuba and Brazil. The virus, endemic to the Amazon and spread by biting midges and mosquitoes, causes symptoms such as fever, headaches, muscle and joint pain, and can lead to severe conditions like meningitis and encephalitis. Pregnant women are particularly at risk due to potential fetal harm. While Florida has seen the majority of cases, there has been one report in New York and another in Jefferson County, Kentucky. Despite no evidence of local transmission in the U.S., the CDC has issued travel advisories and emphasized preventive measures as there are no vaccines or specific treatments available for the virus. Globally, the Pan American Health Organization has issued alerts regarding the spread of Oropouche virus in South America and the Caribbean.